The Alper lab focuses on engineering biology to produce organic molecules of interest such as biofuels, commodity and specialty chemicals, and protein pharmaceuticals. To accomplish these tasks, traditional pathway engineering approaches are merged with novel synthetic biology tools, protein engineering …
Cha HJ, Byrom M, Mead PE, Ellington AD, Wallingford JB, Marcotte EM (2012). Evolutionarily Repurposed Networks Reveal the Well-Known Antifungal Drug Thiabendazole to Be a Novel Vascular Disrupting Agent. PLoS Biology. 10(8):e1001379 | Pubmed
Tabor JJ, Salis H, Simpson ZB, Chevalier AA, Levskaya A, Marcotte EM, Voigt CA, Ellington AD (2009). A Synthetic Genetic Edge Detection Program. Cell. 137:1272-1281 | Pubmed
Gray RS, Abitua PB, Wlodarczyk BJ, Blanchard O, Lee I, Weiss G, Marcotte EM, Wallingford JB, Finnel RH (2009). The planar cell polarity effector protein Fuzzy is essential for targeted membrane trafficking, ciliogenesis, and mouse embryonic development. Nature Cell Biology. 11:1225-1232 | Pubmed
Lee I, Lehner B, Crombie C, Wong W, Fraser AG, Marcotte EM (2008). A single network comprising the majority of genes accurately predicts the phenotypic effects of gene perturbation in Caenorhabditis elegans. Nature Genetics. 40:181-188 | Pubmed
Lu P, Vogel C, Wang R, Yao X, Marcotte EM (2007). Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation. Nature Biotechnol. 25:117-120 | Pubmed