Professor Jiang’s research is focused on systems immunology. A dysfunctional or dysregulated immune system not only fails to offer protection, it can also introduce unnecessary immune responses such as allergies or autoimmune diseases. The key to immune modulation and engineering and regenerative medicine is to understand how the normal immune system works. However, a full understanding of the complex interactions among immune cells and between immune cells and cytokines and chemokines requires a quantitative and systems approach. Using high-throughput sequencing and single-cell analysis in combination with quantitative analysis, Professor Jiang is interested in answering the following questions: How does the immune system develop and age? What are the molecular signatures of autoimmune diseases? Why does the immune system tolerate tumors?
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