George GeorgiouProfessor in Molecular Genetics and Microbiology, Chemical Engineering, and Biomedical Engineering
Main Office:CPE 4.410
Phone:+1 512 471 6975
The Georgiou Lab is currently working primarily on the discovery and development of protein therapeutics and applied immunology by capitalizing on state of the art protein engineering, directed evolution and systems biology technologies. Areas of interest include i) the engineering of human therapeutic enzymes for the treatment of a variety of malignancies; ii) the deconvolution of antibody responses and signatures in disease states; iii) the engineering and optimization of therapeutic antibodies; and iv) the design of proteolytic enzymes that cleave and irreversibly inactivate disease targets.
In parallel, the Georgiou lab has been working for over 20 years on redox homeostasis, disulfide bond formation and protein biogenesis in bacteria, with current projects related to i) the evolution of novel pathways for rewiring electron transfer in E.coli and ii) dissecting the role of LMW thiols in redox homeostasis and cell physiology.