Yearly Archives: 2013

Levy M, Ellington AD (2008) Directed Evolution of Streptavidin Variants Using IVC. Chem Biol 15:979-89.

Li B, Ellington AD, Chen X (2011) Rational, modular adaptation of enzyme-free DNA circuits to multiple detection methods. Nucleic Acids Res 39(16):e110.

The Marcotte lab is developing novel systems-biology approaches to mine the evolutionary relationships between genes. These methods have been used to predict surprising relationships between genes and human disease, including: Finding disease genes from lower organisms. New algorithms (the phenolog …

The Marcotte lab is developing novel systems-biology approaches to mine the evolutionary relationships between genes. These methods have been used to predict surprising relationships between genes and human disease, including: Yeast genes relevant for blood vessel formation in humans Plant …

Bringing Diagnostics to Worldwide Clinics A key focus in the Ellington lab is the development of diagnostics for resource-limited settings. DNA molecules can be used as computers, and these “smart” diagnostics can be embedded into otherwise low-tech dipstick devices. These …

Next-generation immune profiling The advent of next-generation, high-throughput sequencing technology has enabled the sequencing of antibody repertoires at an unprecedented level of detail.  Whereas analysis of the antibody repertoire has been historically confounded by its extraordinary size and diversity, the …