Edward Marcotte

The Marcotte group studies the large-scale organization of proteins, essentially trying to reconstruct the ‘wiring diagrams’ of cells by learning how all of the proteins encoded by a genome are associated into functional pathways, systems, and networks. Such models let us better define the functions of genes, and to link genes to traits and diseases, as we have shown for a variety of developmental processes including angiogenesis, neural crest, and neural tube development. The research is evenly split between experimental and computational approaches, with the former tending to be high-throughput functional genomics and proteomics approaches for studying thousands of genes/proteins in parallel, including mass spectrometry and automated fluorescence microscopy.