Daily Archives: July 3, 2013

The discovery of RNA interference (RNAi) and small regulatory RNAs such as siRNAs and miRNAs, has dramatically changed our understanding of the regulation of gene expression. Consequently, RNAi has generated much excitement due to its regulatory and therapeutic potential. The …

Andreas earned his first degree in biology at the Ludwig Maximilians University Munich and then later a Ph.D. with Alan Fersht in the chemistry department of the University of Cambridge. Following graduation, he did a postdoc with Jeff Schatz at …

Genomic DNA acts as the blueprint for life and all organisms have evolved complex protein machines that faithfully maintain our genetic material. Genomic instability, which arises from defects in these proteins, is a defining feature of most cancers. Elucidating the …

The process by which embryos acquire their final shape involves the coordination of cell fate decisions with cell movement. The Wallingford lab takes an integrated approach to understanding this process in chordate embryos. They combine molecular manipulations, time-lapse imaging, bioinformatics …

Nearly all cells respond to physiological or developmental cues by large-scale transcriptional reprogramming – altering the expression of hundreds to thousands of genes throughout the genome. Such sweeping changes in gene expression also underlie the development of diseases such as …

His research focuses on using evolutionary techniques to engineer biopolymers and cells. Researchers in the Ellington lab select binding species (aptamers) and ribozymes from random sequence populations in order to apply the selected species to solve real-world problems. For example, …

Barrick is broadly interested in understanding evolution as a creative force. His lab uses experiments with populations of bacteria, biomolecules, and digital organisms to study the fundamental constraints and opportunities common to evolving systems. They formulate and test new biological …