April 2010 — “Edward M. Marcotte is looking for drugs that can kill tumors by stopping blood vessel growth, and he and his colleagues at the University of Texas at Austin recently found some good targets — five human genes that are essential for that growth. Now they’re hunting for drugs that can stop those genes from working. Strangely, though, Dr. Marcotte did not discover the new genes in the human genome, nor in lab mice or even fruit flies. He and his colleagues found the genes in yeast.”
In one of the largest and most detailed studies of animal molecular biology ever undertaken, researchers at The University of Texas at Austin and the University of Toronto discovered the assembly instructions for nearly 1,000 protein complexes shared by most kinds of animals, revealing their deep evolutionary relationships.
November 2014 — “The Marcotte and Ellington labs have been awarded 4.5 million dollars by DARPA to develop single molecule protein sequencing technologies. These methods would revolutionize systems biology, bringing the same sensitivity and throughput to protein analysis that NextGen sequencing brought to DNA analysis. The collaboration with chemists Eric Anslyn and Dmitrii Makarov brings together scientists from across the University of Texas at Austin.”
Although his goal is to someday help destroy HIV and other viruses and retroviruses that form persistent, lifelong infections, biologist Chris Sullivan can’t help but admire the strategies that many of these viruses have evolved to evade our defenses.
The Center for systems and Synthetic Biology (CSSB) brings together UT researchers across a range of disciplines to quantitatively understand and engineer the regulatory networks underlying organismal biology.
Hot Science, Cool Talks: Self Diagnostics. Dr. Ellington spoke with the local Austin community about how modern science will provide solutions to low-resource communities, the burgeoning medical needs of an aging population, and our commercial wants and desires. April 4, 2013.